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KMID : 0363320100310030554
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Journal of Korean Oriental Internal Medicine
2010 Volume.31 No. 3 p.554 ~ p.568
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The Effect of Gamitongseong-san(GTS) on Spontaneously Hypertensive Rat(SHR)
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Choi Eun-Hee
Lim Dae-Woong
Jung Tae-San
An Ga-Yong
Chun Hea-Sun
Jeon Sang-Yun
Hong Seok
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Abstract
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Objective:This study was examined to investigate the effect of Gamitongseong-san(GTS) extract on spontaneous hypertension.
Methods:After administering GTS extract to SHR for 4 weeks, we measured anti-oxygen effects, weight of body, heart and kidney, blood pressure, heart rate, aldosterone, catecholamine, electrolyte, uric acid, and BUN.
Results:1. GTS increased 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging activity and superoxide dismutase(SOD) similar activity depending on the concentration. 2. GTS significantly decreased heart weight in spontaneously hypertensive rat. 3. GTS significantly decreased blood pressure and heart rate in SHR. 4. GTS significantly decreased aldosterone. 5. GTS significantly decreased norepinephrine and epinephrine. 6. GTS significantly decreased . 7. GTS significantly decreased BUN.
Conclusions:These results suggest that GTS may be usefully applied for the treatment of hypertension.
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KEYWORD
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Spontaneously hypertensive rat, Gamitongseong-san extract
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